The drug Prednisone has anti-inflammatory, anti-allergic, anti-shock effects. With short-term parenteral use, these effects are realized due to mechanisms common to all glucocorticosteroids: by stabilizing cell membranes, membranes of cell organelles, inhibition of the release of enzymes that damage cells, slowing down the migration of mast cells and the release of inflammatory mediators, reducing capillary permeability, etc. Inhibits synthesis and secretion adrenocorticotropic hormone of the pituitary gland and, as a result, glucocorticosteroids in the adrenal glands.
Where to buy Prednisone(Isotretinoin) without a prescription
|Tablet Strength:||40mg × 360 tablet|
|Best Price:||$ 259,99||Per Pill||$ 0.72|
|Where to buy Prednisone?|
When taken orally, it is well absorbed in the digestive tract. The maximum concentration in blood plasma is reached after 90 minutes. Prednisolone is metabolized mainly in the liver. With intramuscular and intravenous administration of glucocorticosteroids, their effect is shorter than when taken orally.
Most often in rheumatology, at the beginning of the course of treatment, glucocorticosteroid hormones are used in sufficiently high doses corresponding to the degree of disease activity, followed by a gradual decrease.
It should be noted that the effectiveness of Prednisone is most pronounced with a high activity of the inflammatory process. Thus, with the activity of degree I rheumatism, the use of acetylsalicylic acid is more justified than the use of prednisolone; with the activity of the disease of the II-III-degree, prednisolone significantly.
Indications for the use of the drug Prednisone are rheumatoid arthritis, acute rheumatic fever, Addison’s disease, acute adrenal cortex insufficiency, adrenogenital syndrome, bronchial asthma (including for the elimination of status asthma), acute and chronic allergic diseases (drug allergies, serum sickness, urticaria, allergic rhinitis, hypersensitivity to various chemicals, Quincke’s edema), hepatitis, hepatic coma, hypoglycemic conditions, lipoid nephrosis, diseases of the blood system (agranulocytosis, various forms of leukemia, thrombocytopenic purpura, hemolytic anemia), Hodgkin’s disease, diffuse connective tissue diseases ( systemic lupus erythematosus, dermatomyositis, polymyositis, periarteritis nodosa and other systemic vasculitis), severe skin diseases (pemphigus, eczema, exfoliative dermatitis, psoriasis), eye diseases iridocyclitis, uveitis, choroiditis); in pediatrics – with acute rheumatic fever, small chorea, obstructive bronchitis, nephrotic syndrome, to suppress the rejection reaction during organ and tissue transplantation.
Dosage and methods of administration
The dose of the drug is set individually. Inside in acute cases, adults are prescribed an initial dose of 20-30 mg / day. If necessary, the initial dose can be increased to 15–100 mg / day, the maintenance dose is 5–10 mg / day. For parenteral administration (intramuscularly and intravenously), the dose, frequency and duration of drug administration are determined individually. Usually, 30–45 mg of prednisolone is slowly injected intravenously. According to indications, it is administered repeatedly at a dose of 30-60 mg.
Unfortunately, like other drugs, Prednisone has its own side effects. For example:
• dysfunction of the gastrointestinal tract – an irritating effect on the mucous membrane. Therefore, this medication must be taken strictly after meals.
• development of osteoporosis – glucocorticosteroids disrupt the exchange of calcium in the body, contributing to bone loss, which leads to a decrease in their density and increased fragility
• an increase in body weight with a specific increase in the fat layer on the trunk and face and its decrease on the limbs
• fluid retention in the body, which can be manifested by edema and increased blood pressure. This is due to the effect of glucocorticosteroids on water-salt metabolism. Accordingly, it is necessary to control the water balance. You can try taking diuretic drugs, coordinating your actions with your doctor. If these measures do not lead to the normalization of blood pressure, then it is necessary to start taking antihypertensive drugs, which the doctor will recommend.