Benzodiazepine tranquilizers, which include Xanax were first used in medical practice about half a century ago, and today they have no analogues that would surpass them in terms of safety and effectiveness. Due to the wide range of therapeutic effects, low risk of lethal overdose, drugs of this group are widely used in neurology, psychiatry, anesthesiology, rheumatology, general therapy. When taken strictly in accordance with the doctor’s recommendations, Xanax is quite safe, however, self-medication and violation of the recommended dose cause a high probability of adverse reactions, complications and severe dependence.
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Xanax: action and general description
The drug has the following medicinal properties:
• muscle relaxant;
In addition, a wide range of therapeutic efficacy of Alprazolam helps to alleviate the symptoms of concomitant somatic diseases. The drug has antihypoxic, hypotensive, antiarrhythmic activity.
Xanax differs from other drugs of this pharmacological group by more pronounced effectiveness due to its high affinity with specific benzodiazepine receptors of the central nervous system, an average duration of action, due to which daytime drowsiness is either absent or less pronounced.
The principle of action of the drug is based on increasing the sensitivity of benzodiazepine receptors to GABA (γ-aminobutyric acid) — one of the main “inhibitory” neurotransmitters of the central nervous system.
The drug is prescribed in case of:
• anxiety states;
• phobic disorders;
• panic attacks;
• depression (as part of complex therapy);
• withdrawal syndrome with the refusal of alcohol and psychostimulants, accompanied by irritability, aggression, expressed anxiety, psychomotor agitation;
• psychosomatic diseases.
Precautions for use
Reception during pregnancy and lactation. Alprazolam is found in breast milk, therefore, if there are indications for the prescription of the drug, it is recommended to transfer the child to artificial feeding. During pregnancy, the reception of the drug is categorically contraindicated due to the high risk of intrauterine pathologies.
Reception by the elderly. Delayed elimination of the drug is possible, which requires correction of the daily dosage.
Therapy for liver and kidney diseases. Severe pathologies of the urinary and hepatobiliary systems cause changes in the pharmacokinetic properties of Xanax, therefore, it is prescribed at a lower dose.
The possibility of combination with other drugs. During treatment, some antiviral, antifungal, anti-ulcer agents, selective serotonin reuptake inhibitors, antihistamines, anticonvulsants should be taken with caution.
Alcohol and other psychostimulants have the same mechanism of action as benzodiazepines, so their combination can cause a severe overdose.